Which clinical conditions are responsible for thrombocytosis?

Which clinical conditions are responsible for thrombocytosis?

Essential thrombocythemia (ET) was the most common cause of primary thrombocytosis. Among secondary, non-infectious etiologies, tissue damage was the most common, followed by malignancy and iron-deficiency anemia. The most common infectious causes of thrombocytosis were soft-tissue, pulmonary and GI infections.

How do you fix thrombocytosis?

Treatment may include the following:

  1. OTC low-dose aspirin (Bayer) may reduce blood clotting. Shop for low-dose aspirin online.
  2. Prescription medications can lower the risk of clotting or reduce platelet production in the bone marrow.
  3. Platelet pheresis. This procedure removes platelets directly from the blood.

What is the prognosis for thrombocytosis?

The life expectancy of patients with essential thrombocytosis (primary thrombocythemia) is nearly that of the healthy population. Median survival is approximately 20 years. For patients younger than age 60 years, median survival is 33 years.

Is thrombocytosis reversible?

Essential thrombocythemia is a chronic disease with no cure. If you have a mild form of the disease, you may not need treatment. If you have severe symptoms, you may need medicine that lowers your platelet count, blood thinners or both.

Can a virus cause thrombocytosis?

However, secondary thrombocytosis (ST) is frequently observed in children that have a variety of clinical conditions. The potential underlying causes include acute bacterial or viral infections, tissue damage, cancer and chronic inflammation, particularly during early life2,3.

What is the most common cause of high platelet count?

Infection. In both children and adults, infections are the most common cause of an elevated platelet count. 1 This elevation can be extreme, with platelet counts greater than 1 million cells per microliter.

What happens when you have thrombocytosis?

Thrombocytosis refers to having too many platelets in your blood. Platelets are blood cells in plasma that stop bleeding by sticking together to form a clot. Too many platelets can lead to certain conditions, including stroke, heart attack or a clot in the blood vessels.

Is thrombocytosis serious?

Primary thrombocytosis, or essential thrombocythemia, can cause serious bleeding or clotting complications. These can usually be avoided by maintaining good control of the platelet count with medications. After many years of having the disease, however, bone marrow fibrosis (scarring) can develop.

How long can you take hydroxyurea?

But, you should try the hydroxyurea for at least six months before stopping It.

What medication treats thrombocytosis?


  • Hydroxyurea (Droxia, Hydrea.) This drug is the most common prescription used for essential thrombocythemia.
  • Anagrelide (Agrylin).
  • Interferon alfa-2b (Intron A) or peginterferon alfa-2a (Pegasys).

What are the treatment options for reactive thrombocytosis?

Reactive thrombocytosis. Treatment for this condition depends on the cause. If you’ve had significant blood loss from a recent surgery or an injury, your elevated platelet count might resolve on its own. If you have a chronic infection or an inflammatory disease, your platelet count likely will remain high until the condition is under control.

What is the prognosis of secondary thrombocytosis?

Secondary thrombocytosis subsides when the underlying process causing the elevated platelet count resolves (treatment of infection, recovery from surgery, etc.). Even though the platelet count is elevated for a short time (or even indefinitely after splenectomy), secondary thrombocytosis does not typically lead to abnormal blood clotting.

What medications are used to treat thrombocytopenia?

In essential thrombocythemia, medications such as hydroxyurea or anagrelide are used to suppress platelet production by the bone marrow. These medications usually have to be taken indefinitely.

What is the difference between idiopathic and essential thrombocytosis?

Essential thrombocythemia. This term is used when a high platelet count occurs alone (that is, without other blood cell disorders). Idiopathic (id-ee-o-PATH-ick) thrombocythemia. Primary or essential thrombocytosis (these are less favored terms). Secondary or reactive thrombocytosis.