What is the mechanism of action of cytarabine?
What is the mechanism of action of cytarabine?
Mechanism of Action Cytarabine is a pyrimidine analog and is also known as arabinosylcytosine (ARA-C). It is converted into the triphosphate form within the cell and competes with cytidine to incorporate itself in the DNA. The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA.
Why does cytarabine work better on cancer cells?
These cells spread, destroying nearby tissues. Cytarabine works by stopping the cancer cells from multiplying. It does this by inhibiting the production of the cells’ genetic material, DNA and RNA. Both DNA and RNA are needed for growth and multiplication of cells.
Is cytarabine an antimetabolite?
Drug type: Cytarabine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antimetabolite.” (For more detail, see “How cytarabine works” section below).
Which phase is affected by cytarabine?
Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase.
How is cytarabine administered?
Cytarabine 100 mg/ml Injection is a ready to use injection and can be administered by the intravenous and subcutaneous routes. Cytarabine 100 mg/ml Injection should not be administered by the intrathecal route due to the slight hypertonicity of this formulation.
What type of chemotherapy is cytarabine?
Cytarabine is a type of chemotherapy drug and is also known by its brand name, Ara C. It is a treatment for: acute leukaemias (cancers of the blood) some lymphomas (cancers of the lymph glands)
What is cytarabine used to treat?
Cytarabine is used alone or with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML).
What is cytarabine used for?
What is Oxytocin injection used for?
Oxytocin injection is used to begin or improve contractions during labor. Oxytocin also is used to reduce bleeding after childbirth. It also may be used along with other medications or procedures to end a pregnancy.
The mechanism of action of cytarabine is as a Nucleic Acid Synthesis Inhibitor. Cytarabine is an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA.
Is cytarabine a nucleoside inhibitor?
Cytarabine is a Nucleoside Metabolic Inhibitor. The mechanism of action of cytarabine is as a Nucleic Acid Synthesis Inhibitor. Cytarabine is a cytosine analogue and antineoplastic agent used largely in the therapy of acute leukemia.
How is cytarabine converted to triphosphate?
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle.
Does cytarabine kill S phase cells?
Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase.