What is porokeratosis of Mibelli?

What is porokeratosis of Mibelli?

What is porokeratosis of Mibelli? Porokeratosis of Mibelli is a skin condition that usually develops in children or young adults. It begins as one or a few small, brownish bumps that grow into raised, bumpy patches. These patches slowly increase in size over time.

Which variant of porokeratosis is associated with malignant?

Porokeratosis is a premalignant condition[1]; however, all types of porokeratosis can undergo malignant transformation to non-melanoma skin cancer at a rate of 6.9 to 30%. [2][6] Most commonly, the lesion transforms into squamous cell carcinoma. Less frequently, the lesion transforms into basal cell carcinoma.

What causes porokeratosis?

The exact cause of porokeratosis is not known, but genetic factors and having a weak immune system may put you at a greater risk for the condition. Sunlight, UV rays, and other radiation worsen the condition.

What is porokeratosis Plantaris?

Porokeratosis plantaris, palmaris et disseminata (PPPD) is an extremely rare form of porokeratosis in which scaly red-brown annular patches arise on the patient’s palms and soles and spread to the extremities and trunk [2].

Is porokeratosis treatable?

There is no known cure for porokeratosis and treatment is generally disappointing. However, the appearance may improve with the following measures: 5-fluorouracil cream. Calcipotriol cream.

What is Cornoid lamella?

The cornoid lamella is a parakeratotic column overlying a small vertical zone of dyskeratotic and vacuolated cells within the epidermis (Figures 2 and 3). There is also a focal loss of the granular layer.

What is the ICD 10 code for Porokeratosis?

Disseminated superficial actinic porokeratosis (DSAP) L56. 5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

What is the best treatment for porokeratosis?

Topical imiquimod cream has been shown to be effective for treating classic porokeratosis of Mibelli (PM). Ingenol mebutate has shown efficacy in the treatment of PM.

What is the treatment for porokeratosis?

Oral and topical retinoids,1,2 fluorouracil cream,3 vitamin D3 analogues,4 diclofenac gel,5 and imiquimod cream6 have all been used to treat porokeratosis. Surgical options include excision, cryotherapy,7 dermabrasion,8 and laser therapy.

Is porokeratosis and autoimmune disease?

Porokeratosis is considered to result from the inability to eliminate an abnormal keratinocyte clone induced by genetic factors and various stimuli, including sunlight, artificial ultraviolet light, viral infections, immunosuppressive conditions (hematologic malignancies, organ transplants, or autoimmune disease), and …

What is Porokeratosis Ptychotropica?

Porokeratosis is a skin disorder clinically characterized by annular plaques with keratotic borders resembling the Great Wall of China and histopathologically by cornoid lamellae. The disease has several clinical variants.

How is Porokeratosis treated?

What are the signs and symptoms of porokeratosis of mibelli?

Porokeratosis of Mibelli generally has a very specific appearance but some other skin lesions that could be considered include: 1 Psoriasis — multiple well-defined red plaques with silvery white scale; often itchy 2 Intraepidermal squamous cell carcinoma — one or more slowly growing irregular scaly plaques. More

What is disseminated superficial actinic porokeratosis?

Disseminated superficial actinic porokeratosis. Lesions become more prominent in the summer months. Lesions can be inherited in an autosomal dominant fashion; however, most cases are sporadic, appearing in the 3rd to 4th decade Diagnosis can be assisted with the use of dermoscopy to identify the single or double (tram) track at the periphery.

What does a double white track on a mibelli look like?

Occasionally the white track may be a double white track, with brownish discoloration within the furrow, especially in larger lesions such as porokeratosis of Mibelli (PM). The center may show a white homogeneous area, corresponding to an atrophic epithelium.

How do you get rid of mibelli porokeratosis?

There is no known cure for porokeratosis of Mibelli and treatment is generally disappointing. However, the appearance may improve with the following measures: 5-Fluorouracil cream. Calcipotriol cream. Oral acitretin or isotretinoin. Cryotherapy. Dermabrasion. Carbon dioxide laser ablation.