What is non-infective endocarditis?

What is non-infective endocarditis?

Non-infective endocarditis, also known as non-bacterial thrombotic endocarditis (NBTE) or aseptic endocarditis, refers to a rare condition characterised by formation of sterile vegetations. Without treatment, these can lead to valve dysfunction, heart failure, systemic embolism and death.

What are the warning signs of endocarditis?

Common signs and symptoms of endocarditis include:

  • Aching joints and muscles.
  • Chest pain when you breathe.
  • Fatigue.
  • Flu-like symptoms, such as fever and chills.
  • Night sweats.
  • Shortness of breath.
  • Swelling in your feet, legs or abdomen.

What is nonbacterial thrombotic endocarditis?

Nonbacterial thrombotic endocarditis (NBTE) is a rare condition that refers to a spectrum of noninfectious lesions of the heart valves that is most commonly seen in advanced malignancy. NBTE is often an autopsy finding.

How is NBTE diagnosed?

There are no pathognomonic signs and symptoms that allow for the diagnosis of NBTE. Previously Mckay and Wahler [27] outlined a triad consisting of: (1) a disease process known to be associated with NBTE, (2) presence of a heart murmur and (3) evidence of multiple systemic emboli.

What causes non bacterial endocarditis?

Noninfective endocarditis refers to formation of sterile platelet and fibrin thrombi on cardiac valves and adjacent endocardium in response to trauma, circulating immune complexes, vasculitis, or a hypercoagulable state. Symptoms are those of systemic arterial embolism.

What is infective endocarditis?

Infective endocarditis (IE) is an infection of the inner lining of the heart muscle (endocardium) caused by bacteria, fungi, or germs that enter through the bloodstream.

Can you have endocarditis without fever?

Isolated mitral posteromedial papillary endocarditis is a rare entity and highlights that even without fever, murmurs, or constitutional symptoms, severe multisystem infections from endocarditis can occur.

What is the most common cause of infective endocarditis?

Approximately 80% of infective endocarditis cases are caused by the bacteria streptococci and staphylococci. The third most common bacteria causing this disease is enterococci, and, like staphylococci, is commonly associated with healthcare-associated infective endocarditis.

What is Marantic thrombosis?

Abstract. The term nonbacterial thrombotic endocarditis (NBTE), or marantic endocarditis, refers to a spectrum of lesions ranging from microscopic aggregates of platelets to large vegetations on previously undamaged heart valves (most often aortic and mitral) in the absence of a bloodstream bacterial infection.

What does Marantic mean?

adjective Referring to protein-energy malnutrition, as in marantic endocarditis (now better known as non-bacterial thrombotic endocarditis).

Why do non-bacterial thrombotic endocarditis occur?

Non-bacterial thrombotic endocarditis (NBTE) or marantic endocarditis is a non-infectious process affecting normal or degenerative cardiac valves that is due to fibrin thrombi deposits in patients with hypercoagulable states associated with adenocarcinomas of the lung, colon, or pancreas that produce mucin.

What is endocarditis and what causes it?

Endocarditis is caused by bacteria in the bloodstream multiplying and spreading across the inner lining of your heart (endocardium). The endocardium becomes inflamed, causing damage to your heart valves. Your heart is usually well protected against infection so bacteria can pass harmlessly by.

Can a person die from endocarditis?

If acute endocarditis remains untreated, it can be fatal in less than six weeks. Untreated subacute endocarditis can cause death within six weeks to one year. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.