How do you administer aripiprazole depot?
How do you administer aripiprazole depot?
Abilify Maintena is only intended for intramuscular use and should not be administered intravenously or subcutaneously. It should only be administered by a healthcare professional. The suspension should be injected slowly as a single injection (doses must not be divided) into the gluteal or deltoid muscle.
How do you prepare an Aripiprazole injection?
Slowly inject the Sterile Water for Injection into the vial containing the ABILIFY MAINTENA lyophilized powder (see Figure 10). Withdraw air to equalize the pressure in the vial by pulling back slightly on the plunger. Subsequently, remove the needle from the vial.
Can Abilify be given IM?
ABILIFY solution for injection is for intramuscular use. To enhance absorption and minimise variability, injection into the deltoid or deep within the gluteus maximus muscle, avoiding adipose regions, is recommended. ABILIFY solution for injection should not be administered intravenously or subcutaneously.
How many ml is Abilify Maintena 300 mg?
Abilify Maintena comes in two forms: Single dose prefilled dual chamber syringe kits for 300 mg (injection volume of 1.5 ml) and 400 mg doses (injection volume of 2.0 ml) – fewer steps and components. This formulation should be utilized within 30 minutes of reconstitution.
How quickly does aripiprazole depot work?
For the first 2 weeks of the initial depot injection, oral aripiprazole should be continued to allow adequate time for the intramuscular medication to reach adequate plasma concentrations, which we know can take approximately 6–12 days.
Is aripiprazole fast acting?
It must be taken on its own. A doctor or nurse can give you a fast-acting dose of aripiprazole by injection if you are very agitated. You can have a tablet at the same time – under the supervision of a doctor – which will make the effect last longer.
Can you give aripiprazole depot early?
TEST DOSES PRIOR TO ADMINISTRATION With the exception of olanzapine, risperidone, paliperidone and aripiprazole long acting injections, it is recommended that patients are given a small test dose before the onset of the therapeutic dose for treatment, to avoid severe and prolonged adverse effects.
How do I switch from oral Abilify to Maintena?
Aripiprazole long-acting-injection (Abilify Maintena, ARISTADA) [National Drug Monograph]. Typical dose: 6.25-25 mg every 2-4 weeks. General conversion formula: For each 10 mg/day PO, give 12.5 mg decanoate every 3 weeks. Increase by 12.5 mg increments if doses >50 mg needed.
How many mL is Abilify Maintena 400 mg?
Table 3: ABILIFY MAINTENA Reconstituted Suspension Volume to Inject
|400 mg Vial||300 mg Vial|
|Dose||Volume to Inject||Volume to Inject|
|400 mg||2 mL||—|
|300 mg||1.5 mL||1.5 mL|
|200 mg||1 mL||1 mL|
How many mL is ABILIFY MAINTENA 400 mg?
What are depots prescribed for?
A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics.
What is the most common side effect of Abilify?
The most common Abilify side effects in adult patients in clinical trials were nausea, vomiting, constipation, headache, dizziness, movement disorder, anxiety, insomnia and restlessness.
What is the dose adjustment for aripiprazole extended release?
Dose Adjustments. Aripiprazole Extended-Release IM Suspension: -IM extended-release: If there are adverse reactions with 400 mg, consider reducing to 300 mg once a month. MISSED DOSES: Second or Third dose: -If more than 4 weeks and less than 5 weeks have elapsed: Administer as soon as possible.
What is the T Max of dehydro-aripiprazole?
Dehydro-aripiprazole, the active metabolite of aripiprazole, displays a median T max of 5.5 to 12.5 days after multiple doses of 200 to 400 mg administered every 4 weeks. Steady-state concentrations (Css) of aripiprazole are obtained by the fourth dose (16 weeks).
How many milligrams of aripiprazole can you take in one day?
-Patients stable on oral aripiprazole 15 mg/day: Initial dose 662 mg IM once; continue aripiprazole 15 mg orally once a day for 21 days. -Patients stable on oral aripiprazole at least 20 mg/day: Initial dose 882 mg IM; continue oral aripiprazole once a day for 21 days.
How long does it take for aripiprazole to wear off?
A single dose of 200 mg, 300 mg, and 400 mg aripiprazole LAI yields a half-life of 18.9, 24.9, and 10.5 days, respectively, with multiple doses of 300 mg or 400 mg administered every 4 weeks resulting in a mean half-life of 29.9 and 46.5 days, respectively.