Other /

Does hypoxia induce VEGF?

Does hypoxia induce VEGF?

Hypoxia is the principal regulator of VEGF expression, as it is a direct transcriptional target of both HIF-1α and HIF-2α.

What is microvascular endothelial cells?

Vascular endothelial cells are multi-functional cells that line the vessels of the circulatory system. In particular, microvascular endothelial cells are located in the smallest vessels of the circulatory system, such as the capillaries.

What regulates HIF?

Under normal oxygen tension, HIF-1α protein expression is negatively regulated by proteasomal degradation and ubiquitination in a pathway involving von Hippel−Lindau protein (pVHL), a tumor suppressor protein and one of the recognized components of an E3 ubiquitin protein ligase27.

Is HIF a growth factor?

Hypoxia inducible factor-1 is involved in growth factor, glucocorticoid and hypoxia mediated regulation of vascular endothelial growth factor-A in human meningiomas. J Neurooncol.

How does HIF can increase performance through angiogenesis?

HIF likely also contributes to angiogenesis in tumors. Tumors are typically dense and lack their own blood vessels, so most of them have low levels of oxygen. The lack of oxygen causes cancer cells to produce HIF. This activates the secretion of vascular endothelial cell growth factor (VEGF).

What is Huvec cell line?

Human umbilical vein endothelial cells (HUVECs) are cells derived from the endothelium of veins from the umbilical cord. They are used as a laboratory model system for the study of the function and pathology of endothelial cells (e.g., angiogenesis).

What is Hbmec?

Isolated from human brain. HBMEC are cryopreserved at passage one and delivered frozen. Brain microvascular endothelial cells (BMEC), the major component of the blood-brain barrier, limit the passage of soluble and cellular substances from the blood into the brain.